Muscle Physiology Lab
Muscle Physiology Lab
Welcome to Dr. Richard Lieber's Lab
Our lab's goal is to discover treatments for diseases of the muscular system using tools from bioengineering, molecular biology, cell biology, and neuroscience.
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Our Projects
Take a look at a few of the projects we work on everyday.
Skeletal Muscle Design in Animals and People
PROJECT TYPE:
Muscle, Muscle Fibers, Biomedical Engineering
Research Project
Intraoperative Hand Measurements
PROJECT TYPE:
Muscle, Muscle Fibers, Biomedical Engineering
Research Project
Muscle Injury and Repair
PROJECT TYPE:
Muscle, Muscle Fibers, Biomedical Engineering
Research Project
Sarcomere Measurements
PROJECT TYPE:
Muscle Fibers, Muscle, Cerebral Palsy, Muscular Dystrophy, Physiology
Research Project
Selected Publications
Three Distinct Cell Populations Express Extracellular Matrix Proteins and Increase in Number During Skeletal Muscle Fibrosis.
Tissue extracellular matrix provides structural support and creates unique environments for resident cells. However, the identities of cells responsible for creating specific ECM components have not been determined. In striated muscle, the identity of these cells becomes important in disease when ECM changes result in fibrosis and subsequent increased tissue stiffness and dysfunction. Here we describe a novel approach to isolate and identify cells that maintain the ECM in both healthy and…
Skeletal muscle fiber-type specific succinate dehydrogenase activity in cerebral palsy.
Reduced skeletal muscle satellite cell number alters muscle morphology after chronic stretch but allows limited serial sarcomere addition.
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